NCIt definition : A potent angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
Rentiapril competitively binds to and inhibits ACE, thereby blocking the conversion
of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions
of angiotensin II and results in vasodilation. Rentiapril also decreases angiotensin
II-induced aldosterone secretion by the adrenal cortex, which leads to an increase
in sodium excretion and subsequently increases water outflow.;