NCIt definition : A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive
activity. Ramiprilat inhibits ACE, thereby blocking the conversion of angiotensin
I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin
II and leads to vasodilation. This agent also causes an increase in bradykinin levels
and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex,
thereby promoting diuresis and natriuresis.;