Benazeprilat - CISMeF

Preferred Label : Benazeprilat;

NCIt definition : The active metabolite of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Once the prodrug benazepril is metabolized to benazeprilat in the liver, benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.;

UNII : JRM708L703;

InChIKey : MADRIHWFJGRSBP-ROUUACIJSA-N;

CAS number : 86541-78-8;

Chemical formula : C22H24N2O5;

Details

Origin ID

C72907;

UMLS CUI

C0105523;

Currated CISMeF NLP mapping
- benazeprilat [MeSH concept]
- benazeprilat [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- benazeprilat [MeSH concept]
- benazeprilat [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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