Penicillamine - CISMeF

Preferred Label : Penicillamine;

NCIt synonyms : D-Mercaptovaline; Beta-thiovaline; Depamine; D-Penicillamine; Alpha-amino-beta-methyl-beta-mercaptobutyric Acid; 3-Mercapto-D-valine; Beta,Beta-dimethylcysteine;

NCIt related terms : Trolovol; Cuprimine; Mercaptyl; Distamine; Cuprenil; Metalcaptase; Perdolat; .beta.,.beta.-Dimethylcysteine;

NCIt definition : A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. (NCI04);

Alternative definition : NCI-GLOSS: A drug that removes copper from the body and is used to treat diseases in which there is an excess of this metal. It is also being studied as a possible angiogenesis inhibitor in brain tumors.;

UNII : GNN1DV99GX;

InChIKey : VVNCNSJFMMFHPL-VKHMYHEASA-N;

CAS number : 52-67-5;

Drug name : Distamine; Cupripen; Depen; Trolovol; Kelatin; Atamir; Mercaptyl; Pendramine; Metalcaptase; Perdolat; Sufortan; Cuprimine; Cuprenil;

Chemical formula : C5H11NO2S;

NSC code : 81549;

ChEBI ID : CHEBI:7959;

Codes from synonyms : NSC0081549; CDR0000045510;

Details

Origin ID

C729;

UMLS CUI

C0030817;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Penicillamine [ICD-11 Extension code]
- Penicillamine [LOINC component]
- Penicillamine (substance) [SNOMED CT concept]
- Product containing penicillamine (medicinal product) [SNOMED CT concept]
- penicillamine [ATC Code]
- penicillamine [Substance BNPC]
- penicillamine [MeSH concept]
- penicillamine [SNOMED Notion]
- penicillamine [MeSH Descriptor]
Validated automatic mappings to BTNT
- penicillamine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Penicillamine/Pyridoxine [NCIt concept]

Keyword's position in hierarchy(ies) :

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