Adult Ovarian Granulosa Cell Tumor

Preferred Label : Adult Ovarian Granulosa Cell Tumor;

NCIt synonyms : Adult Type Ovarian Granulosa Cell Tumor;

NCIt related terms : Ovarian Granulosa Cell Tumor;

NCIt definition : A low-grade malignant sex cord-stromal tumor that occurs in the ovary and affects middle aged to post-menopausal women. It is composed of granulosa cells in an often fibrothecomatous stroma. The neoplastic cells may form various patterns including the microfollicular, which is characterized by the presence of Call-Exner bodies, macrofollicular, insular, trabecular, and diffuse pattern. Signs and symptoms include abdominal mass, hemoperitoneum, and ascites. Estrogenic and rarely androgenic manifestations may be present. The vast majority of cases present as stage I tumors; however, all tumors have a potential for aggressive clinical course.;

Neoplastic status : Malignant;

Details

Origin ID

C7288;

UMLS CUI

C1332218;

Automatic exact mappings (from CISMeF team)
- Ovarian granulosa cell tumor [MedDRA LLT]
Disease excludes abnormal cell
- Neoplastic Germ Cell [NCIt concept]
- Neoplastic Sertoli Cell [NCIt concept]
- Neoplastic Sex Cord-Stromal Cell Resembling Steroid Hormone-Secreting Cell [NCIt concept]
Disease may have findings
- Abdominal Mass [NCIt concept]
- Call Exner Bodies Present [NCIt concept]
- Gyriform Trabecular Pattern [NCIt concept]
- Insular Pattern [NCIt concept]
- Macrofollicular Structures Present [NCIt concept]
- Menstrual Disorder [NCIt concept]
- Microfollicular Structures Present [NCIt concept]
- Peritoneal Hemorrhage [NCIt concept]
- Postmenopausal Hemorrhage [NCIt concept]
- Solid Growth Pattern [NCIt concept]
Has associated anatomic sites
- Female Reproductive System [NCIt concept]
- Genitourinary System [NCIt concept]
- Ovary [NCIt concept]
- Reproductive System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
disease_has_abnormal_cell
- Neoplastic Cell [NCIt concept]
- Neoplastic Granulosa Cell [NCIt concept]
- Neoplastic Sex Cord-Stromal Cell [NCIt concept]
disease_has_finding
- Adulthood Lesion [NCIt concept]
disease_has_normal_cell_origin
- Granulosa Cell [NCIt concept]
disease_has_primary_anatomic_site
- Female Reproductive System [NCIt concept]
- Ovary [NCIt concept]
disease_may_have_associated_disease
- Peritoneal Effusion [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Loss of Chromosome 6q [NCIt concept]
- Tetrasomy 12 [NCIt concept]
- Trisomy 12 [NCIt concept]
disease_may_have_molecular_abnormality
- FOXL2 Gene Mutation [NCIt concept]

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