Ganaxolone - CISMeF

Preferred Label : Ganaxolone;

NCIt synonyms : GNX;

NCIt definition : An orally bioavailable synthetic analog of the neuroactive steroid allopregnanolone and positive allosteric modulator of the gamma-aminobutyric acid (GABA)-A receptor, with anxiolytic, sedative, antidepressant and anticonvulsant activities. Upon oral administration, ganaxolone specifically targets and binds to the allosteric sites of the synaptic and extrasynaptic GABA-A receptor-chloride ionophore complex in the central nervous system (CNS). This leads to an increase in the opening of chloride channels, membrane hyperpolarization, increases the inhibitory effect of GABA on the CNS, and inhibits neurotransmission. This blocks seizure propagation and elevates seizure thresholds.;

UNII : 98WI44OHIQ;

InChIKey : PGTVWKLGGCQMBR-FLBATMFCSA-N;

CAS number : 38398-32-2;

Drug name : Ztalmy;

Molecule name : CCD-1042; CCD 1042;

Chemical formula : C22H36O2;

Details

Origin ID

C72793;

UMLS CUI

C0537150;

Automatic exact mappings (from CISMeF team)
- ganaxolone [ATC Code]
Currated CISMeF NLP mapping
- ganaxolone [MeSH concept]
- ganaxolone [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ganaxolone [ATC Code]
- ganaxolone [MeSH concept]
- ganaxolone [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients