Preferred Label : Epalrestat;
NCIt definition : An orally available, a non-competitive, reversible inhibitor of aldose reductase (AR),
with potential antineoplastic, antioxidant, and anti-inflammatory activities. Upon
oral administration, epalrestat non-competitively binds to AR, a polyol pathway enzyme
that catalyzes reactive oxygen species (ROS)-initiated lipid peroxidation-generated
lipid aldehydes and their glutathione conjugates, which have been implicated in the
activation of transcription factors such as nuclear factor kappa-light-chain-enhancer
of activated B cells (NF-kappa B) and activator protein-1 (AP-1), which control the
transcription of many inflammatory cytokines. Increased inflammatory cytokines and
growth factors promote cell proliferation, a primary feature in the tumorigenesis
process. AR is overexpressed in several oxidative stress- and inflammation-related
conditions, including cancer.;
UNII : 424DV0807X;
InChIKey : CHNUOJQWGUIOLD-NFZZJPOKSA-N;
CAS number : 82159-09-9;
Chemical formula : C15H13NO3S2;
Origin ID : C72762;
UMLS CUI : C0095278;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
