NCIt definition : A broad-spectrum polymyxin antibiotic against most aerobic Gram-negative bacteria
except Proteus bacteria. Colistimethate is a mixture of methanesulfonate derivatives
of cyclic polypeptides colistin A and B from Bacillus colistinus or B. polymyxa. Colistin
functions as a surfactant which penetrates into and disrupts the bacterial cell membrane,
thereby resulting in bactericidal effect.;
Semantic type(s)