NCIt definition : An agent belonging to the glitazone (thiazolidinedione) class of antidiabetic agents
with antihyperglycemic activity. Ciglitazone also exerts anti-inflammatory activity
through the modulation of nuclear factor-kappaB-mediated pathways. In addition, this
agent inhibits angiogenesis by reducing vascular endothelial growth factor (VEGF)
production and inhibits growth of melanoma cells by inhibiting the expression of (C-X-C
motif) ligand 1 (CXCL1). This agent is the prototypical compound for the thiazolidinedione
class, and has never been marketed.;