NCIt definition : A broad-spectrum, semisynthetic penicillin derivative with antibacterial activity.
Aspoxicillin binds to and inactivates penicillin-binding proteins (PBPs) located on
the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with
the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength
and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening
of the bacterial cell wall, eventually causing cell lysis.;