" /> Nitroxoline - CISMeF





Preferred Label : Nitroxoline;

NCIt synonyms : 8-Hydroxy-5-nitroquinoline;

NCIt definition : An orally bioavailable quinoline antibiotic, with potential antineoplastic activity. Upon oral administration, nitroxoline may induce apoptosis and inhibit tumor cell proliferation in NF1-null Schwann cells in neurofibromatosis type I through as of yet undisclosed mechanism of actions, other than inhibiting the RAS/mitogen-activated protein kinase (MAPK) pathway, and possibly through modulating mitochondrial function. NF1 encodes neurofibromin which inactivates Ras. Loss of neurofibromin in neurofibromatosis type I results in increased Ras activity, which promotes the transcription of genes that drives tumor cell growth and proliferation. As an antibiotic, nitroxoline inhibits bacterial RNA polymerase.;

UNII : A8M33244M6;

InChIKey : RJIWZDNTCBHXAL-UHFFFAOYSA-N;

CAS number : 4008-48-4;

Drug name : Nicene;

Molecule name : HLX 1502; HLX-1502;

Chemical formula : C9H6N2O3;

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13/08/2025


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