" /> Protionamide - CISMeF





Preferred Label : Protionamide;

NCIt synonyms : Prothionamide; 2-Propylpyridine-4-carbothioamide;

NCIt definition : A thioamide derivative with antitubercular activity. Protionamide forms a covalent adduct with bacterial nicotinamide adenine dinucleotide (NAD), PTH-NAD, which competitively inhibits 2-trans-enoyl-ACP reductase (inhA), an enzyme essential for mycolic acid synthesis. This results in increased cell wall permeability and decreased resistance against cell injury eventually leading to cell lysis. Mycolic acids, long-chain fatty acids, are essential mycobacterial cell wall components and play a key role in resistance to cell injury and mycobacterial virulence.;

UNII : 76YOO33643;

InChIKey : VRDIULHPQTYCLN-UHFFFAOYSA-N;

CAS number : 14222-60-7;

Chemical formula : C9H12N2S;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
28/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.