Preferred Label : Nanafrocin;
NCIt synonyms : Nanaomycin A; (1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic
Acid;
NCIt definition : A quinone antibiotic isolated from Streptomyces rosa var. notoensis with activity
against gram-positive bacteria, mycoplasmas and fungi. Within an organism, nanaomycin
A is first reduced by flavin or NADH dehydrogenase then rapidly autooxidized leading
to the production of singlet molecular oxygen (O2-). The increase in intracellular
O2- results in inhibition of DNA, RNA and cell-wall peptidoglycan synthesis. Further,
nanaomycin A may have antineoplastic properties resulting from a reduction in DNA
methylation by inhibiting DNA methyltransferase 3B (DNMT3B) and reactivating the tumor
suppressor gene RASSF1A.;
UNII : 8XBV72641V;
InChIKey : ZCJHPTKRISJQTN-JGVFFNPUSA-N;
CAS number : 52934-83-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 52934-83-5
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G-SRS /a ;
Molecule name : OS 3966-A;
Chemical formula : C16H14O6;
ChEBI ID : CHEBI:48202;
Origin ID : C72594;
UMLS CUI : C0068391;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
