Preferred Label : Pomalidomide;
NCIt synonyms : 4-Aminothalidomide; 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide; 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;
NCIt related terms : CC-4047;
NCIt definition : An orally bioavailable derivative of thalidomide with potential immunomodulating,
antiangiogenic and antineoplastic activities. Although its exact mechanism of action
has yet to be fully elucidated, pomalidomide appears to inhibit TNF-alpha production,
enhance the activity of T cells and natural killer (NK) cells and enhance antibody-dependent
cellular cytotoxicity (ADCC). In addition, pomalidomide may inhibit tumor angiogenesis,
promote cell cycle arrest in susceptible tumor cell populations, and stimulate erythropoeisis.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of prostate cancer, multiple
myeloma, and other types of cancer. Pomalidomide is a form of the drug thalidomide.
It stops the growth of blood vessels, stimulates the immune system, and may kill cancer
cells. Pomalidomide is a type of angiogenesis inhibitor and a type of immunomodulatory
agent.;
UNII : D2UX06XLB5;
InChIKey : UVSMNLNDYGZFPF-UHFFFAOYSA-N;
CAS number : 19171-19-8;
Drug name : Actimid; Pomalyst; Imnovid;
Molecule name : CC-4047; CC 4047;
Chemical formula : C13H11N3O4;
Codes from synonyms : CDR0000559141; CDR0000589401; 410;
PubMed : 16085014;
Origin ID : C72560;
UMLS CUI : C2347624;
CISMeF manual mappings
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
