NCIt related terms : Localized scleroderma [morphea];
NCIt definition : A chronic disorder, possibly autoimmune, marked by excessive production of collagen
which results in hardening and thickening of body tissues. Localized scleroderma typically
affects the skin, with formation of patches or lines of thick and unyielding tissue;
there can be muscle and underlying tissue involvement as well as occasional joint
complications. The affected areas of skin can be restrictive and disfiguring. The
shape, depth and location of the affected area is used to classify one of the four
types of local scleroderma. An individual can have a combination of localized scleroderma
types.;
Alternative definition : NICHD: An autoimmune disorder marked by excessive production of collagen resulting
in hardening and thickening of skin, with formation of patches or lines of thick and
unyielding tissue. There can also be musculoskeletal and underlying tissue involvement.
The affected areas of skin can be restrictive and disfiguring.;