Preferred Label : Phosphatidylcholine-Bound Silybin;
NCIt definition : An oral preparation of the flavonoid silybin with potential antioxidant and chemopreventive
activities. Silybin, also known as silibinin, is a mixture of two stereoisomers, denoted
silybin A and silybin B, and is the major active constituent of silymarin, a mixture
of flavonolignans extracted from blessed milk thistle (Silybum marianum). Silybin
modulates P-glycoprotein (P-gp)-mediated cellular efflux; has oxygen radical-scavenging
effects; inhibits the arachidonic acid pathway; and inhibits various cytochrome P450
enzymes. This agent may also exhibit anti-angiogenic activity, possibly by inducing
endothelial cell apoptosis via modulation of the transcription factor NF-kB, the Bcl-2
family of proteins, and caspases. Complexing silybin with phosphatidylcholine increases
its bioavailability.;
Drug name : Silybin-Phytosome;
Origin ID : C71883;
UMLS CUI : C2347508;
Semantic type(s)
- concept_is_in_subset
