Polymorphic Post-Transplant Lymphoproliferative Disorder

Preferred Label : Polymorphic Post-Transplant Lymphoproliferative Disorder;

NCIt synonyms : Polymorphic PTLD; Polymorphic B-Cell Lymphoma; Polymorphic B-Cell Post-Transplant Lymphoproliferative Disorder;

NCIt definition : A clonal B-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a polymorphic B-cell infiltrate composed of small and medium sized lymphocytes, immunoblasts, and plasma cells. In some cases, reduction of the immunosuppression therapy may lead to regression of the lesions. In other cases the lesions may progress to lymphoma.;

Neoplastic status : Uncertain Malignant Potential;

ICD-O code : 9971/3;

Details

Origin ID

C7183;

UMLS CUI

C1301361;

Currated CISMeF NLP mapping
- Polymorphic lymphoproliferative disorder following transplant (disorder) [SNOMED CT concept]
- Polymorphic post-transplant lymphoproliferative disorder [ICD-11 Subcategory]
- Post-transplant lymphoproliferative disorder, polymorphic (morphologic abnormality) [SNOMED CT concept]
Disease excludes abnormal cell
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Extranodal Disease [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Lymphadenopathy [NCIt concept]
- Necrotic Change [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
- Organ System [NCIt concept]
See also inter- (CISMeF)
- Polymorphic post transplant lymphoproliferative disorder (morphologic abnormality) [Inactive SNOMED CT concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Polymorphic lymphoproliferative disorder following transplant (disorder) [SNOMED CT concept]
- Polymorphic post transplant lymphoproliferative disorder (morphologic abnormality) [Inactive SNOMED CT concept]
- Post-transplant lymphoproliferative disorder, polymorphic (morphologic abnormality) [SNOMED CT concept]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_has_abnormal_cell
- Abnormal Hematopoietic and Lymphoid Cell [NCIt concept]
- Abnormal Lymphocyte [NCIt concept]
- Neoplastic B-Immunoblast [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic Medium-Sized Lymphocyte [NCIt concept]
- Neoplastic Plasma Cell [NCIt concept]
- Neoplastic Small B-Lymphocyte [NCIt concept]
disease_has_finding
- Borderline Lesion [NCIt concept]
- Immunodeficiency [NCIt concept]
- Immunosuppression-Related Post-Transplant Toxicity [NCIt concept]
- Polymorphic Cellular Infiltrate [NCIt concept]
- Therapy-Related Toxicity [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_may_have_abnormal_cell
- Reed-Sternberg-Like Cell [NCIt concept]
disease_may_have_associated_disease
- EBV Infection [NCIt concept]

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