NCIt definition : A preparation of cytokine-induced killer (CIK) cells, with potential immunopotentiating
and antineoplastic activities. CIK cells are generated from peripheral blood lymphocytes
(PBLs) by sequential ex vivo incubation with a monoclonal antibody against CD3 (anti-CD3),
interferon-gamma (IFN-g) and interleukin-2 (IL-2), followed by expansion. CIK cells
are heterogeneous cells comprising CD3 CD56- T cells, CD3-CD56 natural killer (NK)
cells, and CD3 CD56 natural killer T (NKT) cells. Upon administration of the CIK
cells into the patient, the terminally differentiated CD3- and CD56-positive subset
of the CIK cells primarily exert the direct MHC-unrestricted tumor killing activity.;
Currated CISMeF NLP mapping