Preferred Label : Anti-Denatured Collagen Monoclonal Antibody TRC093;
NCIt synonyms : Recombinant Humanized IgG1k Monoclonal Antibody TRC093;
NCIt definition : A humanized, affinity-matured IgG1k antibody directed against denatured collagens
(I-IV) with potential antiangiogenic and antineoplastic activities. Anti-denatured
collagen recombinant monoclonal antibody TRC093 binds to multiple epitopes on denatured
collagens, inhibiting proteolytic collagen-mediated signaling in the extracellular
matrix (ECM) that is important to tumor angiogenesis, tumor growth, and metastasis.
The epitopes on denatured collagen bound by this antibody are considered cryptic because,
in vivo, they are accessible only on the subendothelial basement membrane of tumors
or in normal tissues undergoing neovascularization.;
Molecule name : TRC093; D93; MT293;
NCI Metathesaurus CUI : CL376136;
Origin ID : C71749;
UMLS CUI : C2347905;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
