Preferred Label : Cytomegalovirus pp65-Specific Cytotoxic T Lymphocytes;
NCIt synonyms : CMV pp65-Specific CTL;
NCIt definition : Cytotoxic T lymphocytes (CTLs) specifically reactive to the cytomegalovirus (CMV)
phosphoprotein pp65 with potential antiviral activity. To prepare CMV pp65-specific
cytotoxic T lymphocytes in vitro, dendritic cells (DCs) are pulsed with CMV pp65 epitopes
and then used to stimulate and propagate CMV pp65-specific cytotoxic T lymphocytes
from peripheral blood mononuclear cells (PBMNCs); the CMV pp65-specific cytotoxic
T lymphocyte population is then expanded so as to be sufficient for use in adoptive
T lymphocyte therapy. When administered into a patient post-allogeneic hematopoietic
stem cell transplantation, this agent may elicit a specific CTL response against CMV-infected
host cells, which may result in the resolution of CMV infection. The CMV pp65 protein
(65 kDa lower matrix phosphoprotein), the primary component of the enveloped subviral
particle, is an immunodominant target for helper and cytotoxic T lymphocyte responses
to CMV.;
NCI Metathesaurus CUI : CL376143;
Origin ID : C71747;
UMLS CUI : C2348033;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
