Preferred Label : S-Adenosyl-L-Methionine Disulfate P-Toluene-Sulfonate;
NCIt synonyms : SAMe Disulfate P-Toluene-Sulfonate; S-Adenosyl-L-methionine Disulfate Tosylate; S-Adenosyl-L-Methionine Disulfate p-Toluenesulfonate; S-Adenosyl-L-methionine Disulfate Tosilate; S-adenosylmethionine Tosylate Disulfate; (3S)-5'-((3-Amino-3-carboxypropyl)methylsulfonio)-5'-deoxyadenosine, Disulfate-methylbenzenesulfonate;
NCIt definition : The disulfate salt of the stable p-toluene-sulfonate complex of s-adenosyl-L-methionine
(SAMe) with chemopreventive activity. SAMe disulfate p-toluene-sulfonate undergoes
hydrolytic conversion to its active compound SAMe within cells. Although the mechanism
of action is largely unknown, SAMe attenuates experimental liver damage and prevents
experimental hepatocarcinogenesis. In addition, SAMe may reduce mitochondrial cytochrome
C release, caspase 3 activation, and poly(ADP-ribose) polymerase cleavage, and attenuate
okadaic acid-mediated hepatocyte apoptosis in a dose-dependent manner. SAMe is an
essential compound in cellular transmethylation reactions and a precursor of polyamine
and glutathione synthesis in the liver; SAMe deficiency is associated with chronic
liver disease-associated decreases in the activity of methionine adenosyltransferase
1A (MAT1A), the enzyme that catalyzes the production of SAMe as the first step in
methionine catabolism.;
UNII : 564ROC9U09;
InChIKey : XDCFCHNAIMYBAZ-XQVUROGGSA-N;
CAS number : 97540-22-2;
Drug name : SAM-e Complete;
NCI Metathesaurus CUI : CL376146;
Origin ID : C71745;
UMLS CUI : C2347987;
Semantic type(s)
- concept_is_in_subset
