Preferred Label : Nucleotide Analogue GS 9219;
NCIt synonyms : 9-(2-phosphonylmethoxyethyl)guanine nucleotide analogue prodrug GS 9219;
NCIt definition : A prodrug of the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)guanine
(PMEG) with potential antineoplastic activity. Formulated to selectively accumulate
in lymphocytes, nucleotide analogue GS 9219 is converted to its active metabolite,
PMEG diphosphate (PMEGpp), via enzymatic hydrolysis, deamination, and phosphorylation;
subsequently, PMEGpp is incorporated into nascent DNA chains by DNA polymerases, which
may result in the termination of DNA synthesis, S-phase cell cycle arrest, and the
induction of apoptosis in susceptible lymphoma cell populations.;
Molecule name : GS9219;
NCI Metathesaurus CUI : CL376149;
Origin ID : C71742;
UMLS CUI : C4547392;
Semantic type(s)
- concept_is_in_subset
