Preferred Label : Survivin Sur1M2 Peptide Vaccine;
NCIt definition : A modified recombinant nonapeptide (LMLGEFLKL) derived from the anti-apoptosis protein
survivin with potential immunopotentiating and antineoplastic activities. Upon administration,
survivin Sur1M2 peptide vaccine may elicit humoral and cellular immune responses against
survivin-expressing cancers, resulting in decreased tumor cell proliferation and tumor
cell death. The survivin protein inhibits caspase activation and apoptosis; it is
undetectable in normal adult tissues but is expressed by several human cancers including
lung, colon, breast, pancreas, and prostate cancer as well as hematopoietic malignancies
and skin cancers.;
NCI Metathesaurus CUI : CL376129;
Origin ID : C71741;
UMLS CUI : C2348618;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
