Nifurtimox - CISMeF

Preferred Label : Nifurtimox;

NCIt definition : A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function.;

UNII : M84I3K7C2O;

InChIKey : ARFHIAQFJWUCFH-IZZDOVSWSA-N;

CAS number : 23256-30-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 23256-30-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Lampit;

Molecule name : 4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine-1,1-dioxide; BAY 2502; BAYER 2502;

Chemical formula : C10H13N3O5S;

Details

Origin ID

C71734;

UMLS CUI

C0028073;

Currated CISMeF NLP mapping
- Nifurtimox [ICD-11 Extension code]
- Nifurtimox (substance) [SNOMED CT concept]
- Product containing nifurtimox (medicinal product) [SNOMED CT concept]
- nifurtimox [Substance BNPC]
- nifurtimox [MeSH Descriptor]
- nifurtimox [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Nifurtimox [ICD-11 Extension code]
- Nifurtimox (substance) [SNOMED CT concept]
- Product containing nifurtimox (medicinal product) [SNOMED CT concept]
- nifurtimox [ATC Code]
- nifurtimox [Substance BNPC]
- nifurtimox [MeSH Descriptor]
- nifurtimox [MeSH concept]
Validated automatic mappings to BTNT
- bayer 2502 [SNOMED Notion]
- nifurtimox [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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