Preferred Label : Quarfloxin;
NCIt synonyms : 5-Fluoro-N-(2-((2S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-(3-(pyrazin-2- yl)pyrrolidin-1-yl)-3H-benzo(b)pyrido(3,2,1-kl)phenoxazine-2-carboxamide; 3H-Benzo(b)pyrido(3,2,1-kl)phenoxazine-2-carboxamide, 5-fluoro-N-(2-((2S)- 1-methyl-2-pyrrolidinyl)ethyl)-3-oxo-6-(3-pyrazinyl-1-pyrrolidinyl)-; Quarfloxacin;
NCIt definition : A fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the
interaction between the nucleolin protein and a G-quadruplex DNA structure in the
ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is
overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction
in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and
tumor cell apoptosis.;
UNII : 8M31J5031Q;
InChIKey : WOQIDNWTQOYDLF-CGAIIQECSA-N;
CAS number : 865311-47-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 865311-47-3
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G-SRS /a ;
Molecule name : CX-3543;
Chemical formula : C35H33FN6O3;
Origin ID : C71726;
UMLS CUI : C2347728;
Semantic type(s)
- concept_is_in_subset
