Preferred Label : Evofosfamide;
NCIt synonyms : HAP TH-302; Phosphorodiamidic Acid, N,N'-bis(2-bromoethyl)-, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl
Ester; Hypoxia-Activated Prodrug TH-302;
NCIt definition : A hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM)
conjugated with 2-nitroimidazole, with potential antineoplastic activity. When exposed
to hypoxic conditions, such as those found in hypoxic tumors, the 2-nitroimidazole
moiety of evofosfamide is reduced. This releases the DNA-alkylating Br-IPM moiety,
which introduces intra- and inter-strand DNA crosslinks in nearby cells; the crosslinks
inhibit both DNA replication and cell division, and may lead to apoptosis of cells
in the tumor. The inactive form of the prodrug is stable under normoxic conditions,
which may limit systemic toxicity.;
UNII : 8A9RZ3HN8W;
InChIKey : UGJWRPJDTDGERK-UHFFFAOYSA-N;
CAS number : 918633-87-1;
Molecule name : TH-302;
Origin ID : C71722;
UMLS CUI : C4080092;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
