NCIt definition : A long-acting, pegylated recombinant variant of human granulocyte colony-stimulating
factor (G-CSF) with immunomodulating activity. Pegylated granulocyte colony stimulating
factor MAXY-G34 contains multiple non-naturally occurring lysines that have been introduced
into alpha helixes of wild type human G-CSF as pegylation sites; other naturally occurring
lysine residues have been removed to prevent pegylation and the variant G-CSF is pegylated
with methoxypolyethylene glycol succinimidyl propionate (mPEG SPA) at three amino
acid residues. Similar to endogenous G-CSF, this agent binds to and activates specific
cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation
and selected neutrophil functions. A difference in the degree of pegylation may account
for the extended half-life of this agent compared to pegfilgrastim which is pegylated
at only one amino acid residue.;