Preferred Label : Givinostat;
NCIt synonyms : Gavinostat; HDAC Inhibitor ITF2357;
NCIt definition : An orally bioavailable hydroxymate inhibitor of histone deacetylase (HDAC) with potential
anti-inflammatory, anti-angiogenic, and antineoplastic activities. Givinostat inhibits
class I and class II HDACs, resulting in an accumulation of highly acetylated histones,
followed by the induction of chromatin remodeling and an altered pattern of gene expression.
At low, nonapoptotic concentrations, this agent inhibits the production of pro-inflammatory
cytokines such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-6 and interferon-gamma.
Givinostat has also been shown to activate the intrinsic apoptotic pathway, inducing
apoptosis in hepatoma cells and leukemic cells. This agent may also exhibit anti-angiogenic
activity, inhibiting the production of angiogenic factors such as IL-6 and vascular
endothelial cell growth factor (VEGF) by bone marrow stromal cells.;
UNII : 5P60F84FBH;
InChIKey : YALNUENQHAQXEA-UHFFFAOYSA-N;
CAS number : 497833-27-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 497833-27-9
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G-SRS /a ;
Molecule name : ITF2357;
Chemical formula : C24H27N3O4;
Origin ID : C71716;
UMLS CUI : C2987670;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
