Preferred Label : Citatuzumab Bogatox;
NCIt synonyms : Anti-EpCAM Antibody Fragment-Bouganin Fusion Protein; Anti-EpCAM-Bouganin Fusion Protein;
NCIt definition : A fusion protein immunotoxin consisting of a humanized, single-chain monoclonal antibody
Fab fragment specific for the epithelial cell adhesion molecule (EpCAM) conjugated
with a modified bouganin cytotoxin with potential antineoplastic activity. Citatuzumab
bogatox binds to EpCAM, delivering modified bouganin cytotoxin directly to EpCam-positive
tumor cells, which may result in the inhibition of tumor cell protein synthesis and
tumor cell death. EpCAM, a cell surface protein, is expressed by a variety of tumor
cells and is frequently found in head and neck cancers. Bouganin is a plant-derived
ribosome-inactivating protein (RIP), a toxic plant N-glycosidase that depurinates
the universally conserved alpha-sarcin loop of ribosomal rRNA, inactivating the ribosome
and preventing protein synthesis. Compared to unmodified bouganins, modified bouganins
may have a reduced propensity to activate human T cells.;
UNII : 23J303Z5CA;
CAS number : 945228-49-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 945228-49-9
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : VB6-845;
NCI Metathesaurus CUI : CL376117;
Origin ID : C71694;
UMLS CUI : C2346811;
Semantic type(s)
- concept_is_in_subset
