Casopitant - CISMeF

Preferred Label : Casopitant;

NCIt synonyms : Casopitant Base;

NCIt definition : A centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK-receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.;

UNII : 3B03KPM27L;

InChIKey : XGGTZCKQRWXCHW-WMTVXVAQSA-N;

CAS number : 414910-27-3;

Molecule name : GW679769;

Chemical formula : C30H35F7N4O2;

Details

Origin ID

C71635;

UMLS CUI

C2347566;

Automatic exact mappings (from CISMeF team)
- Casopitant [ICD-11 Extension code]
Currated CISMeF NLP mapping
- casopitant [MeSH concept]
- casopitant [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- casopitant [ATC Code]
- casopitant [MeSH concept]
- casopitant [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- casopitant [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Casopitant Mesylate [NCIt concept]
is_free_acid_or_base_form_of
- Casopitant Mesylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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