Preferred Label : Allogeneic CD4 Memory Th1-like T Cells/Microparticle-bound Anti-CD3/anti-CD28;
NCIt synonyms : Allogeneic CD4 Specific Memory Th1-Like T Cell;
NCIt definition : A preparation consisting of allogeneic, differentiated Th1-like T cells bound to T
cell-stimulating monoclonal antibodies with potential antitumor activity. More specifically,
allogeneic CD4 memory Th1-like T cells/microparticle-bound anti-CD3/anti-CD28 are
composed of a proprietary preparation of mismatched, allogeneic differentiated CD4
memory Th1-like T cells bound to paramagnetic, epoxy-covered 4.5 micron microparticles
with covalently bound anti-CD3/anti-CD28 monoclonal antibodies at a 2:1 bead:cell
ratio. The CD4 memory Th1-like T cells are derived from precursors found in the circulation
of a normal donor. Stimulated by the microparticle-bound monoclonal antibodies, the
infused T cells produce pro-inflammatory, anti-tumor cytokines such as like IFN-gamma,
TNF-beta, and IL-2, disabling tumor immune avoidance mechanisms and stimulating the
host immune system to both reject the infused T cells and kill tumor cells.;
Drug name : AlloStim;
NCI Metathesaurus CUI : CL378252;
Origin ID : C71540;
UMLS CUI : C2348423;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
