" /> Acadesine - CISMeF





Preferred Label : Acadesine;

NCIt synonyms : Arasine; 5-Amino-1beta-D-ribofuranosylimidazole-4-carboxyamide; 5-Amino-4-imidazolecarboxamide Ribofuranoside; AICA-riboside;

NCIt definition : A 5-aminoimidazole-4-carboxamide (AICA) riboside, a ribnucleoside analog, and a nucleotide biosynthesis precursor with B cell pro-apoptotic activity. Following cellular uptake, acadesine is phosphorylated to AICA ribotide (ZMP), which mimics 5'-adenosine monophosphate (AMP). Both AMP-activated protein kinase (AMPK) and AMPK kinase (AMPKK) are activated by ZMP, which appears to be necessary for the induction of apoptosis. Acadesine-induced apoptosis also appears to require cytochrome c release from mitochondria and caspase activation and is p53-independent. However, the exact mechanism of acadesine-induced apoptosis is unknown. T cells are significantly less susceptible than B cells to acadesine-induced apoptosis. AMPK regulates several cellular systems including the cellular uptake of glucose, the beta-oxidation of fatty acids, protein synthesis, and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.;

UNII : 53IEF47846;

InChIKey : RTRQQBHATOEIAF-UUOKFMHZSA-N;

CAS number : 2627-69-2;

Drug name : Protara;

Molecule name : GP-1-110;

Chemical formula : C9H14N4O5;

NSC code : 105823;

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08/05/2025


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