Preferred Label : Pexastimogene Devacirepvec;
NCIt synonyms : Thymidine Kinase-Deleted Vaccinia-GM-CSF JX-594 Vaccine; Thymidine Kinase-deleted Vaccinia-hGM-CSF; VAC GM-CSF; Thymidine Kinase (-) Vaccinia-GM-CSF JX-594 Vaccine;
NCIt definition : An oncolytic thymidine kinase (TK)-deleted vaccinia poxvirus expressing human GM-CSF
(hGM-CSF) with antineoplastic activity. Upon intratumoral or intravenous administration,
pexastimogene devacirepvec selectively infects and lyses tumor cells. While vaccinia
displays a natural tumor cell tropism, deletion of the TK gene increases the tumor
selectivity of vaccinia by limiting viral replication to cells expressing high levels
of TK, such as certain cancer cells. hGM-CSF expression by this agent helps recruit
antigen presenting cells (APCs), such as dendritic cells (DCs) and macrophages, to
virally infected tumor cells, thereby initiating an antitumoral immune response.;
UNII : K82DG47I0G;
CAS number : 1058624-46-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1058624-46-6
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G-SRS /a ;
Drug name : Pexa-vec;
Molecule name : JX-594; TG-6006; JX 594;
NCI Metathesaurus CUI : CL378156;
Origin ID : C71533;
UMLS CUI : C2348784;
Semantic type(s)
- concept_is_in_subset
