Anti-CD33 Monoclonal Antibody-DM4 Conjugate AVE9633

Preferred Label : Anti-CD33 Monoclonal Antibody-DM4 Conjugate AVE9633;

NCIt synonyms : Anti-CD33-DM4 Conjugate;

NCIt definition : An immunoconjugate consisting of the humanized monoclonal antibody huMy9-6 conjugated to the cytotoxic maytansinoid DM4 with potential antineoplastic activity. The monoclonal antibody portion of anti-CD33 monoclonal antibody-DM4 conjugate AVE9633 specifically binds to the cell surface antigen CD33 expressed on myeloid leukemia cells; upon internalization, the DM4 moiety is released, binds tubulin, and disrupts microtubule assembly/disassembly dynamics, resulting in the inhibition of cell division and cell growth in myeloid leukemia cells that express CD33. CD33 is expressed on normal non-pluripotent hematopoietic stem cells as well as on myeloid leukemia cells.;

NCI Metathesaurus CUI : CL378287;

Details

Origin ID

C71523;

UMLS CUI

C3501972;

Currated CISMeF NLP mapping
- AVE9633 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- AVE9633 [MeSH concept]
- AVE9633 [MeSH Supplementary Concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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