Preferred Label : SN-38-Loaded Polymeric Micelles NK012;
NCIt synonyms : SN-38-Loaded Polymeric Micelle;
NCIt definition : A formulation consisting of polymeric micelles loaded with the irinotecan metabolite
SN-38 with potential antineoplastic activity. SN-38-loaded polymeric micelles NK012
is an SN-38-releasing nanodevice constructed by covalently attaching SN-38 to the
block copolymer PEG-PGlu, followed by self-assembly of amphiphilic block copolymers
in an aqueous milieu. SN-38 (7-ethyl-10-hydroxy-camptothecin), a biological active
metabolite of the prodrug irinotecan (CPT-11), binds to and inhibits topoisomerase
I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting
in DNA breaks, inhibition of DNA replication, and apoptosis. SN-38 has been reported
to exhibit up to 1,000-fold more cytotoxic activity against various cancer cells in
vitro than irinotecan. This formulation increases the water-solubility of SN-38 and
allows the delivery of higher doses of SN-38 than those achievable with SN-38 alone.;
Molecule name : NK012;
NCI Metathesaurus CUI : CL376227;
Origin ID : C71521;
UMLS CUI : C2348115;
Semantic type(s)
- concept_is_in_subset
