NCIt synonyms : DRB4; HLA-DR4B; Major Histocompatibility Complex, Class II, DR Beta 4 wt Allele; Human Leucocyte Antigen DRB4; Human Leukocyte Antigen DRB4; HLA-DRB4*; DR4;
NCIt definition : Human HLA-DRB4 wild-type allele is located in the vicinity of 6p21.3 and is approximately
15 kb in length. This allele, which encodes HLA class II histocompatibility antigen,
DRB4 beta chain protein, plays a role in the regulation of antigen presentation. The
gene is polymorphic and typing is often performed to determine histocompatibility
for hematopoietic stem cell transplantation.;
NCIt note : The HLA-DRB4 gene is expressed as multiple isoforms that determine the HLA-DR53 antigen
serotype. The gene product is a beta subunit for the HLA-DR complex.;
Semantic type(s)