Preferred Label : HLA-Matched Donor Mononuclear Cell-Enriched Leukocytes Apocell;
NCIt synonyms : ApoCell;
NCIt definition : A preparation of allogeneic HLA-matched leukocytes treated with a derivative of placental
protein 14 (PP14) with potential immunomodulating activity. PP14 derivative-treated
HLA-matched donor mononuclear cell-enriched leukocytes contain at least fifty-five
percent early-apoptotic T cells; after infusion and when processed by recipient dendritic
cells, early-apoptotic T cells may help induce a decrease in the donor effector T-cell
responses against the recipient of an allogeneic hematopoietic stem cell (HSC) transplant,
thereby minimizing allogeneic HSC transplant-related graft-versus-host disease (GVHD).
PP14, a 162 amino acid glycosylated protein secreted by the late secretory phase endometrium,
binds to T cells in a carbohydrate fashion and has been shown to induce T-cell apoptosis;
maternal immune tolerance to the fetus and pregnancy-related remissions of autoimmune
disease may involve PP14-induced T cell apoptosis.;
NCI Metathesaurus CUI : CL376208;
Origin ID : C71162;
UMLS CUI : C2348928;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
