Preferred Label : High-Selenium Brassica juncea;
NCIt synonyms : BJ-Se;
NCIt definition : A formulation of the mustard plant Brassica juncea grown in a medium that has been
enriched with the trace element selenium with potential chemopreventive and chemopotentiating
activities. Brassica juncea hyperaccumulates trace elements in soil. Selenium amino
acid species found in selenized Brassica juncea include methylselenomethionine (MeSeMet)
and methylselenocysteine (MeSeCys); both may be incorporated into selenoproteins in
vivo. Selenium functions as a cofactor for antioxidant enzymes such as glutathione
peroxidases and thioredoxin reductase, which protect cells from the free radical damage.
In addition, in vitro MeSeCys has been shown to potentiate the antitumor effects of
the irinotecan metabolite SN-38, by inducing phosphorylation of checkpoint kinase
2 (chk2) at threonine 68, which results in poly(ADP-ribose) polymerase cleavage, caspase
3 activation, and DNA fragmentation.;
Alternative definition : NCI-GLOSS: Brassica juncea that has been grown in high levels of selenium. Brassica
juncea is a plant of the cabbage family that has been used in some cultures to treat
certain medical problems, including arthritis, colds, stomach disorders, and tumors.
The plant stores minerals, including selenium which may stop tumor cells from growing.
High-selenium Brassica juncea is being studied in the treatment of cancer. Brassica
juncea is also known as Indian mustard.;
NCI Metathesaurus CUI : CL377692;
Codes from synonyms : CDR0000614167;
Origin ID : C71154;
UMLS CUI : C2348971;
Semantic type(s)
- concept_is_in_subset
