[18F]-labeled Substance P Antagonist Receptor Quantifier

Preferred Label : [18F]-labeled Substance P Antagonist Receptor Quantifier;

NCIt synonyms : [18F]SPA-RQ; 18F SPA-RQ; (18F)-L-829165; L-829165 F-18;

NCIt related terms : SPA-RQ F-18;

NCIt definition : A radioconjugate consisting of the positron emitting radioisotope fluorine F 18 conjugated to the substance P antagonist receptor quantifier (SPA-RQ) used in radioimaging. [18F]-labeled substance P antagonist receptor quantifier is an antagonist of the neurokinin 1 (substance P) receptor (NK1R) and can function as a positron emission tomography (PET) imaging agent for detecting NK1R-expressing cells and tissues. NK1Rs are frequently expressed on the plasma membranes of tumor cells from glioblastoma and breast and pancreatic carcinomas.;

Alternative definition : NCI-GLOSS: A radiolabeled substance being studied in PET imaging of the brain. It is also being studied as a way to find where cancer cells have spread in patients with pancreatic cancer. It binds to cell receptors for substance P, also known as neurokinin-1, which is found on nerve cells and on some types of cancer cells, such as pancreatic cancer cells. [18F]-labeled substance P antagonist receptor quantifier is a type of PET radioligand and a type of radiolabeled neurokinin-1 receptor antagonist.;

UNII : 4YL3GT1EV9;

CAS number : 262598-99-2;

Codes from synonyms : CDR0000613892; CDR0000613891;

Details

Origin ID

C71071;

UMLS CUI

C1872494;

Automatic exact mappings (from CISMeF team)
- (2-fluoromethoxy-5-(5-trifluoromethyltetrazol-1-yl)benzyl)(2-phenylpiperidin-3-yl)amine [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- (18F)SPA-RQ [MeSH concept]
Semantic type(s)
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- (18F)SPA-RQ [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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