NCIt definition : A galectin-binding polysaccharide derived from citrus pectin with potential antineoplastic
activity. Apoptosis inducer GCS-100 binds to the carbohydrate-binding domain of the
lectin galectin-3, which may result in apoptosis mediated through mitochondria/caspase
activation cascades; this agent may overcome tumor growth mediated through anti-apoptotic
protein Bcl-2, heat-shock protein 27 (Hsp27), and nuclear factor-kappa B (NF-kB).
Galectin-3, a chimeric molecule consisting of both carbohydrate recognition and collagen-like
domains, interacts with a variety of carbohydrate and protein ligands to form pentamers
with unique crosslinking abilities; this lectin also exhibits anti-apoptotic properties,
perhaps, in part, through the regulation of intracellular signaling pathways.;