Preferred Label : Dornase Alfa Inhalation Solution;
NCIt synonyms : Recombinant Human Deoxyribonuclease I Inhalation Solution; rhDNAse Inhalation Solution;
NCIt related terms : Pulmozyme;
NCIt definition : A highly purified solution of recombinant human deoxyribonuclease I (rhDNAse) with
selective DNA cleaving activity. Administrated through inhalation of the nebulized
solution, dornase alpha catalyzes DNA degradation in viscous airway secretions, which
may render airway secretions less viscous, thus promoting the clearing of airway mucous
plugging and improvement in pulmonary function.;
Alternative definition : NCI-GLOSS: A drug given in an aerosol mist to decrease the thickness of mucus in the
lungs of patients with cystic fibrosis. It is also being studied as a treatment to
reduce the thickness of saliva in patients being treated for head and neck cancer.
Dornase alfa inhalation solution contains an enzyme that breaks the DNA in mucus into
small pieces and makes the mucus thinner.;
Drug name : Pulmozyme; Tigerase;
Codes from synonyms : CDR0000597138; CDR0000597139;
Origin ID : C70980;
UMLS CUI : C2348327;
Semantic type(s)
- concept_is_in_subset
