Preferred Label : Vector-peptide Conjugated Paclitaxel;
NCIt synonyms : Taxol-Angiopep Conjugate;
NCIt definition : A proprietary conjugate of paclitaxel with antineoplastic activity. Similar to the
free drug, the paclitaxel moiety in vector-peptide conjugated paclitaxel binds to
and stabilizes tubulin molecules, promoting assembly of microtubules and inhibiting
tubulin disassembly which results in the inhibition of cell division. The Kunitz domain-derived
vector-peptide carries the conjugated paclitaxel through the blood brain barrier (BBB),
bypassing the transmembrane p-glycoprotein (P-gp) efflux pump, which may result in
higher concentrations of paclitaxel in the brain parenchyma.;
Origin ID : C70971;
UMLS CUI : C2349111;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
