Fluorine F 18 Fluoroethylcholine

Preferred Label : Fluorine F 18 Fluoroethylcholine;

NCIt synonyms : 18F-Fluoroethylcholine; Fluorine 18 Ethylcholine;

NCIt related terms : FLUOROETHYLCHOLINE ION F-18;

NCIt definition : Ethylcholine labeled with fluorine F 18, a positron-emitting isotope. Fluorine F 18 fluoroethylcholine incorporates into tumor cells through an active, carrier-mediated transport mechanism for choline and then is phosphorylated intracellularly by choline kinase, yielding a phosphoryl derivative, and finally is integrated into cellular phospholipids, probably primarily into a phosphatidyl derivative; concentration of this agent in tumor cells as various fluorine F 18 fluoroethylcholine derivatives enables tumor imaging using positron emission tomography (PET). Choline kinase, the enzyme responsible for the phosphorylation of choline, is frequently up-regulated in human tumor cell lines.;

UNII : 290587400Z;

InChIKey : HVTQGIFBNBMSGE-JZRMKITLSA-N;

CAS number : 188709-02-6;

NCI Metathesaurus CUI : CL375797;

Details

Origin ID

C70594;

UMLS CUI

C2348690;

Automatic exact mappings (from CISMeF team)
- fluoroethylcholine [MeSH Supplementary Concept]
Semantic type(s)
- Element, Ion, or Isotope [UMLS semantic type]
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
UMLS correspondences (same concept)
- fluoroethylcholine (18F) [ATC Code]
Validated automatic mappings to BTNT
- fluoroethylcholine (18F) [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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