NCIt definition : The orally bioavailable acetate salt of norethindrone, a synthetic progestin with
some anabolic, estrogenic, and androgenic activities. As do all progestins, norethindrone
binds to and activates nuclear progesterone receptors (PRs) in target tissues such
as the pituitary and reproductive system; ligand-receptor complexes are translocated
to the nucleus where they bind to progesterone response elements (PREs) located on
target genes, followed by various transcriptional events and histone acetylation.
Physiological effects include the inhibition of luteinizing hormone (LH) release,
an increase in the endometrial luteal-phase, and alterations in endocervical mucus
secretion.;
UNII : 9S44LIC7OJ;
InChIKey : IMONTRJLAWHYGT-ZCPXKWAGSA-N;
CAS number : 51-98-9;
Drug name : Ortho Micronor; Norlutate; Aygestin; Nor-Q.D.;