Central Nervous System Yolk Sac Tumor

Preferred Label : Central Nervous System Yolk Sac Tumor;

NCIt synonyms : Yolk Sac Tumor of the Central Nervous System; Yolk Sac Tumor of the CNS; Yolk Sac Tumor of CNS; Yolk Sac Tumor of Central Nervous System; CNS Yolk Sac Tumor;

NCIt definition : A malignant germ cell tumor of the central nervous system composed of primitive-appearing epithelial cells - putatively representing yolk sac endoderm - set in a loose, variably cellular, and often conspicuously myxoid matrix, resembling extra-embryonic mesoblast. Eosinophilic hyaline globules immunoreactive for AFP are a diagnostic feature. (WHO);

Neoplastic status : Malignant;

Details

Origin ID

C7011;

UMLS CUI

C1337040;

Automatic exact mappings (from CISMeF team)
- Yolk sac tumour of the central nervous system [ICD-11 More detail]
- central nervous system endodermal sinus tumor [DO Concept]
Currated CISMeF NLP mapping
- Yolk sac tumor of central nervous system [ORDO Disease]
DO Cross reference
- central nervous system endodermal sinus tumor [DO Concept]
Disease excludes abnormal cell
- Malignant Primitive Germ Cell [NCIt concept]
- Malignant Round Germ Cell with Glycogen-Rich Cytoplasm and Round Nucleus [NCIt concept]
- Neoplastic Sex Cord-Stromal Cell [NCIt concept]
Disease may have findings
- Alpha Fetoprotein Increased [NCIt concept]
- Cytoplasmic Hyaline Globules Present [NCIt concept]
- Honeycomb Pattern [NCIt concept]
- Schiller-Duval Body [NCIt concept]
- Sinusoidal Growth Pattern [NCIt concept]
Excludes anatomical site(s)
- Gonad [NCIt concept]
Has associated anatomic sites
- Central Nervous System [NCIt concept]
- Nervous System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Yolk sac tumor of central nervous system [ORDO Disease]
- Yolk sac tumor of central nervous system (disorder) [SNOMED CT concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Malignant Germinomatous Cells Present [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Germ Cell [NCIt concept]
disease_has_finding
- Malignant Cellular Infiltrate [NCIt concept]
- Mitotic Activity [NCIt concept]
disease_has_normal_cell_origin
- Germ Cell [NCIt concept]
disease_has_normal_tissue_origin
- Germinal Layer [NCIt concept]
disease_has_primary_anatomic_site
- Central Nervous System [NCIt concept]

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