Central Nervous System Embryonal Carcinoma

Preferred Label : Central Nervous System Embryonal Carcinoma;

NCIt synonyms : Embryonal Carcinoma of CNS; Embryonal Carcinoma of the Central Nervous System; Embryonal Carcinoma of the CNS;

NCIt definition : A malignant germ cell tumor of the central nervous system composed of large cells that proliferate in cohesive nests and sheets. In rare occasions, tumor cells may replicate the structure of the early embryo, forming embryoid bodies replete with germ discs and miniature amniotic cavities. Additional morphologic characteristics include enlarged nucleoli, abundant clear to somewhat violet-hued cytoplasm, a high mitotic rate and zones of coagulative necrosis. (Adapted from WHO);

Neoplastic status : Malignant;

Details

Origin ID

C7010;

UMLS CUI

C1333377;

Automatic exact mappings (from CISMeF team)
- Embryonal carcinoma of the central nervous system [ORDO Disease]
- central nervous system embryonal carcinoma [DO Concept]
DO Cross reference
- central nervous system embryonal carcinoma [DO Concept]
Disease excludes abnormal cell
- Malignant Primitive Germ Cell [NCIt concept]
- Malignant Round Germ Cell with Glycogen-Rich Cytoplasm and Round Nucleus [NCIt concept]
- Neoplastic Sex Cord-Stromal Cell [NCIt concept]
Excludes anatomical site(s)
- Gonad [NCIt concept]
Has associated anatomic sites
- Central Nervous System [NCIt concept]
- Nervous System [NCIt concept]
Has cytogenetic abnormalities
- i(12p) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- central nervous system embryonal carcinoma [DO Concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Malignant Germinomatous Cells Present [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Large Germ Cell with Abundant Cytoplasm [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Germ Cell [NCIt concept]
disease_has_finding
- Geographic Necrosis [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Pseudoglandular Pattern [NCIt concept]
- Pseudopapillary Pattern [NCIt concept]
disease_has_normal_cell_origin
- Germ Cell [NCIt concept]
disease_has_normal_tissue_origin
- Germinal Layer [NCIt concept]
disease_has_primary_anatomic_site
- Central Nervous System [NCIt concept]

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