Nitracrine - CISMeF

Preferred Label : Nitracrine;

NCIt definition : An acridine derivative with potential cytostatic and antitumor activities. Although the exact mechanism of action has not been fully elucidated, nitracrine induces the unwinding of supercoiled DNA and binds to the DNA through intercalation, forming drug-DNA adducts and DNA interstrand crosslinks. This inhibits RNA synthesis, protein production, cell growth, DNA replication and cell proliferation; altogether, this may promote apoptosis. Since cancer cells have increased metabolism and proliferate at an increased rate, nitracrine may induce tumor cell apoptosis.;

UNII : 712MLZ30SB;

InChIKey : YMVWGSQGCWCDGW-UHFFFAOYSA-N;

CAS number : 4533-39-5;

Chemical formula : C18H20N4O2;

Details

Origin ID

C694;

UMLS CUI

C0028120;

Currated CISMeF NLP mapping
- nitracrine [MeSH Descriptor]
- nitracrine [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- nitracrine [MeSH Descriptor]
- nitracrine [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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