NCIt definition : An acridine derivative with potential cytostatic and antitumor activities. Although
the exact mechanism of action has not been fully elucidated, nitracrine induces the
unwinding of supercoiled DNA and binds to the DNA through intercalation, forming drug-DNA
adducts and DNA interstrand crosslinks. This inhibits RNA synthesis, protein production,
cell growth, DNA replication and cell proliferation; altogether, this may promote
apoptosis. Since cancer cells have increased metabolism and proliferate at an increased
rate, nitracrine may induce tumor cell apoptosis.;
UNII : 712MLZ30SB;
InChIKey : YMVWGSQGCWCDGW-UHFFFAOYSA-N;
CAS number : 4533-39-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 4533-39-5
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