Preferred Label : Mast Cell Stabilizer TF002;
NCIt definition : A small molecule with mast cell stabilizing activity. Mast cell stabilizer TF002 inhibits
the formation of lipid rafts of mast cell membranes that contain the signaling machinery
which triggers the release of mast cell allergic and inflammatory mediators. Inhibition
of lipid raft assembly by this agent results in mast cell stabilization, preventing
mast cell degranulation and the release of the inflammatory mediators involved in
type I allergic reactions (histamine, leukotrienes, prostaglandins, and cytokines).
The assembly of the signaling machinery in mast cell lipid rafts, specialized membrane
microdomains rich in cholesterol and sphingolipids, is initiated by IgE binding to
its receptor on the mast cell surface; subsequently, allergens crosslink with the
IgE/receptor complex and other proteins and lipids are recruited into the signaling
machinery.;
Molecule name : TF002;
NCI Metathesaurus CUI : CL375376;
Origin ID : C69146;
UMLS CUI : C2347075;
Semantic type(s)
- concept_is_in_subset
