Preferred Label : Cationic Liposome-Encapsulated Paclitaxel;
NCIt definition : A cationic liposome preparation of paclitaxel with antineoplastic activity. Paclitaxel,
the active ingredient in cationic liposome-encapsulated paclitaxel, binds to tubulin
and inhibits the disassembly of microtubules, resulting in the inhibition of mitosis
and cellular proliferation, and apoptosis. Cationic liposome encapsulation of paclitaxel
allows the delivery of high doses of paclitaxel to target tissues while minimizing
systemic toxicity. Tumor endothelial cells may preferentially bind and internalize
cationic liposomes.;
Drug name : EndoTAG-1; LipoPac;
Molecule name : MBT-0206;
Origin ID : C69130;
UMLS CUI : C2347569;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
