Preferred Label : Anpocogin;
NCIt synonyms : rNAPc2; Recombinant Nematode Anticoagulant Protein c2;
NCIt definition : An 85-amino acid recombinant peptide derived from protein c2 of the hemophagocytic
hookworm Ancylostoma caninum (a common canine parasite) with anticoagulant activity.
Anpocogin binds to circulating activated factor X (FXa) or zymogen factor X (FX) to
form a binary complex which subsequently binds to and inhibits membrane-bound activated
factor VII/tissue factor complex (FVIIa/TF). When administered prophylactically, this
agent may reduce the incidence of deep venous thrombosis without hemostatic compromise.
Because rNAPc2 inhibits the formation of the FVIIa/TF protease complex, which may
play a role in the cellular signaling of both metastatic and angiogenic processes,
it may impede tumor progression.;
UNII : 3TTT9ZD93F;
CAS number : 2725767-44-0;
Molecule name : AB-201;
NCI Metathesaurus CUI : CL371851;
Origin ID : C69129;
UMLS CUI : C2347906;
Semantic type(s)
- concept_is_in_subset
